CCDC88A Gene Summary [Human]
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | CCDC88A |
| Official Name | coiled-coil domain containing 88A [Source:HGNC Symbol;Acc:HGNC:25523] |
| Ensembl ID | ENSG00000115355 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 88A, Galpha-interacting vesicle-associated protein, Akt-phosphorylation enhancer, girdin, girders of actin filaments |
| Synonyms | A430106j12rik, APE, C130096N06Rik, C330012F17Rik, coiled-coil domain containing 88A, D130005J21Rik, FLJ10392, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, LOC100042985, LOC100044467, LOC55580, PEHO, PEHOL, RGD1306694 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCDC88A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hook domain-containing proteins superfamily
- Autophagy protein 16 (ATG16)
- Ciliary protein causing Leber congenital amaurosis disease
- insulin receptor binding
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- Putative golgin subfamily A member 2-like protein 5
- chromosome segregation protein SMC, common bacterial type
- GEF domain
- Prefoldin subunit
- Myosin-like coiled-coil protein
- actin binding
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- protein kinase binding
- Tropomyosin like
- Hyaluronan mediated motility receptor N-terminal
- SH2-domain binding
- rad50
- epidermal growth factor receptor binding
- HOOK domain
- protein kinase C binding
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- vascular endothelial growth factor receptor binding
- phosphatidylinositol binding
- protein kinase activator
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- Domain of unknown function (DUF4686)
- microtubule binding
- RIM-binding protein of the cytomatrix active zone
- GDP-dissociation inhibitor
- prefoldin
- guanyl-nucleotide exchange factor
- protein homodimerization
- Intermediate filament protein
- PDZ binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- colon adenoma formation
- PEHO-like syndrome
- gastric cancer
- kidney disease
- organismal death
- major depression
- memory deficits
- systemic lupus erythematosus
role in cell
- apoptosis
- migration
- phosphorylation in
- expression in
- proliferation
- invasion by
- Gap 0-Gap 1 phase
- quantity
- cell viability
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Golgi region
- cellular membrane
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- centriole
- cell-cell contacts
- cytosol
- nucleoplasm
- transport vesicles
- cytoplasmic vesicles
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCDC88A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- small GTPase mediated signal transduction
- nervous system development
- positive regulation of epidermal growth factor receptor signaling pathway
- TOR signaling cascade
- positive regulation of flagellum assembly
- regulation of cell proliferation
- maintenance of protein location in plasma membrane
- regulation of actin cytoskeleton organization
- cytoskeleton-dependent intracellular transport
- positive regulation of stress fiber assembly
- lamellipodium assembly
- activation of protein kinase activity
- regulation of neuron projection development
- cytoplasmic microtubule organization
- cell migration
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
- centrosome
- centriole
- cytoplasm
- membrane
- Golgi to ER transport vesicle
- cytosol
- cytoplasmic vesicle
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein serine/threonine kinase activator activity
- protein homodimerization activity
- GDP-dissociation inhibitor activity
- guanyl-nucleotide exchange factor activity
- epidermal growth factor receptor binding
- phosphatidylinositol binding
- protein kinase B binding
- insulin receptor binding
- SH2 domain binding
- microtubule binding
- actin binding
- G-protein alpha-subunit binding
- vascular endothelial growth factor receptor 2 binding
- dynein light intermediate chain binding
- G-protein gamma-subunit binding