B3GALT5 Gene Summary [Human]
This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]
Details
| Type | Protein Coding |
| Official Symbol | B3GALT5 |
| Official Name | beta-1,3-galactosyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:920] |
| Ensembl ID | ENSG00000183778 |
| Bio databases IDs | |
| Aliases | beta-1,3-galactosyltransferase 5, homolog of C. elegans Bt toxin resistance gene bre-5, GlcNAc-beta-1,3-galactosyltransferase 5 |
| Synonyms | 1190002B21Rik, B3GalT-V, B3GalTx, B3T5, Beta-1,3-galactosyltransferase 5, beta-1,3-GalTase 5, beta3Gal-T5, beta-3-Gx-T5, GLCT5, LOC105372805, UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5, UDP-Gal:betaGlcNAc β 1,3-galactosyltransferase, polypeptide 5, β-1,3-galactosyltransferase 5, β-1,3-GalTase 5, β-3-Gx-T5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human B3GALT5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase
- galactosyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- organismal death
- flu
- COVID-19
- diabetic nephropathy
- acute myeloid leukemia
- alcoholism
- suicide attempt
role in cell
- synthesis in
- apoptosis
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human B3GALT5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- protein O-linked glycosylation
- lipid metabolic process
- protein glycosylation
- oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity