PTX3 Gene Summary [Human]
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
Details
| Type | Protein Coding |
| Official Symbol | PTX3 |
| Official Name | pentraxin 3 [Source:HGNC Symbol;Acc:HGNC:9692] |
| Ensembl ID | ENSG00000163661 |
| Bio databases IDs | |
| Aliases | pentraxin 3, long pentraxin 3, Tumor necrosis factor-inducible gene 14 protein |
| Synonyms | LOC682447, pentraxin 3, pentraxin related gene, TNFAIP5, TSG-14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- virion binding
- Concanavalin A-like lectin/glucanases superfamily
- binding protein
- LamG
- pentraxin domain
- protein binding
- polysaccharide binding
- identical protein binding
Pathways
Biological processes and signaling networks where the PTX3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- neurodegeneration
- metastatic colorectal cancer
- organismal death
- diabetes mellitus
- early-onset preeclampsia
- septic shock
- streptozotocin-induced diabetes
- idiopathic pulmonary fibrosis
- bronchopulmonary aspergillosis
role in cell
- phosphorylation in
- proliferation
- apoptosis
- expression in
- growth
- migration
- synaptic transmission in
- production in
- activation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
- apical cell surfaces
- membrane blebs
- extracellular matrix
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- inflammatory response
- negative regulation of viral entry into host cell
- response to yeast
- innate immune response
- extracellular matrix organization
- positive regulation of phagocytosis
- opsonization
- ovarian cumulus expansion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- specific granule lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- (1->3)-beta-D-glucan binding
- virion binding
- identical protein binding
- protein binding
- complement component C1q binding