XPOT Gene Summary [Human]
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | XPOT |
| Official Name | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] |
| Ensembl ID | ENSG00000184575 |
| Bio databases IDs | |
| Aliases | exportin for tRNA |
| Synonyms | 1110004L07RIK, 3110065H13Rik, exportin for tRNA, EXPORTIN-T, EXPORTIN(TRNA), exportin, tRNA (nuclear export receptor for tRNAs), tRNA exportin, XPO3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XPOT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- Exportin-T
- Exportin 1-like protein
- protein binding
- Importin-beta N-terminal domain
- Ran binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nuclear pores
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XPOT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA export from nucleus
- intracellular protein transport
- tRNA re-export from nucleus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nuclear matrix
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- tRNA binding