P2RY8 Gene Summary [Human]
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | P2RY8 |
| Official Name | P2Y receptor family member 8 [Source:HGNC Symbol;Acc:HGNC:15524] |
| Ensembl ID | ENSG00000182162 |
| Bio databases IDs | |
| Aliases | P2Y receptor family member 8 |
| Synonyms | P2Y8, P2Y receptor family member 8 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the P2RY8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Turner syndrome
- advanced-stage typical follicular lymphoma
- follicular non-Hodgkin disease
- advanced cancer
- IG-MYC translocation positive Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- limited-stage typical follicular lymphoma
- plasma cell myeloma
regulated by
role in cell
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- phospholipase C-activating G-protein coupled receptor signaling pathway
- G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled purinergic nucleotide receptor activity