LSAMP Gene Summary [Human]
This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | LSAMP |
| Official Name | limbic system associated membrane protein [Source:HGNC Symbol;Acc:HGNC:6705] |
| Ensembl ID | ENSG00000185565 |
| Bio databases IDs | |
| Aliases | limbic system associated membrane protein, IgLON family member 3 |
| Synonyms | 5430428I19, AW046674, B130007O04Rik, D930023J12Rik, Gm29907, IGLON3, Lam, LAMP, limbic system-associated membrane protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LSAMP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- Huntington disease
- insomnia
- lung cancer
- cytomegalovirus infection
- self-abusive behavior
- atrial premature complex
- epithelial ovarian cancer
- neuroticism
regulated by
- N-methyl-D-aspartate
- GATAD2B
- W7
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
- cytosol
- presynaptic membrane
- postsynaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LSAMP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding