NPAP1 Gene Summary [Human]
This intronless retrogene is located in the Prader-Willi syndrome region on chromosome 15. This gene exhibits tissue-specific imprinting. Expression in adult testis and brain is biallelic, while expression in fetal brain is monoallelic and only from the paternal chromosome. The encoded protein is associated with the nuclear pore complex. [provided by RefSeq, Mar 2021]
Details
| Type | Protein Coding |
| Official Symbol | NPAP1 |
| Official Name | nuclear pore associated protein 1 [Source:HGNC Symbol;Acc:HGNC:1190] |
| Ensembl ID | ENSG00000185823 |
| Bio databases IDs | |
| Aliases | nuclear pore associated protein 1 |
| Synonyms | C15orf2, nuclear pore associated protein 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- POM121 family
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA export from nucleus
- protein import into nucleus
- spermatogenesis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- intracellular membrane-bounded organelle
- plasma membrane
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- structural constituent of nuclear pore
- nuclear localization sequence binding