LRRC15 Gene Summary [Human]
Enables collagen binding activity; fibronectin binding activity; and laminin binding activity. Involved in negative regulation of protein localization to plasma membrane; positive regulation of cell migration; and receptor-mediated virion attachment to host cell. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LRRC15 |
| Official Name | leucine rich repeat containing 15 [Source:HGNC Symbol;Acc:HGNC:20818] |
| Ensembl ID | ENSG00000172061 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 15 |
| Synonyms | 5430427N11Rik, leucine rich repeat containing 15, LIB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRRC15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- laminin binding
- Leucine rich repeat
- collagen binding
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- fibronectin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- osteosarcoma
- osteosarcomagenesis
- breast ductal carcinoma in situ
- ductal in situ breast cancer
- colorectal cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- migration
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- extracellular vesicles
- cell surface
- cellular membrane
- apical membrane
- extracellular matrix
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRRC15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral entry into host cell
- virion attachment, binding of host cell surface receptor
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding
- fibronectin binding
- laminin binding