FFAR4 Gene Summary [Human]
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | FFAR4 |
| Official Name | free fatty acid receptor 4 [Source:HGNC Symbol;Acc:HGNC:19061] |
| Ensembl ID | ENSG00000186188 |
| Bio databases IDs | |
| Aliases | free fatty acid receptor 4 |
| Synonyms | BMIQ10, Ffa4, free fatty acid receptor 4, GPR120, GPR129, GT01, KPG 013, O3FAR1, OB10Q, PGR4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FFAR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- fatty acid binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the FFAR4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ARRB2
- fatty acid
disease
- lung adenocarcinoma
- neoplasia
- obesity
- organismal death
- hyperglycemia
- lung adenocarcinoma formation
- impaired glucose tolerance
- insulin resistance
- hepatic steatosis
- osteopenia
role in cell
- phosphorylation in
- expression in
- cell viability
- activation in
- production in
- apoptosis
- degradation in
- signaling in
- differentiation
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cilia
- cellular membrane
- basal bodies
- primary cilia
- lysosome membrane
- endosomal membrane
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FFAR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of brown fat cell differentiation
- G-protein coupled receptor signaling pathway
- negative regulation of inflammatory response
- negative regulation of interleukin-1 beta production
- negative regulation of somatostatin secretion
- phospholipase C-activating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- hormone secretion
- positive regulation of osteoblast differentiation
- elevation of cytosolic calcium ion concentration
- white fat cell differentiation
- brown fat cell differentiation
- regulation of glucose transport
- positive regulation of glucagon secretion
- inflammatory response
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- cellular response to hormone stimulus
- detection of chemical stimulus involved in sensory perception of taste
- negative regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cilium
- endosome membrane
- cilium membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- fatty acid binding
- taste receptor activity
- peptide binding