CLCNKA Gene Summary [Human]
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | CLCNKA |
| Official Name | chloride voltage-gated channel Ka [Source:HGNC Symbol;Acc:HGNC:2026] |
| Ensembl ID | ENSG00000186510 |
| Bio databases IDs | |
| Aliases | chloride voltage-gated channel Ka |
| Synonyms | chloride voltage-gated channel Ka, CLC-K1, hClC-Ka |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLCNKA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- CBS domain
- Voltage gated chloride channel
- chloride channel
- protein binding
- identical protein binding
- voltage-gated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLCNKA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal absorption
- transepithelial chloride transport
- chloride transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- metal ion binding
- voltage-gated chloride channel activity