TRIB3 Gene Summary [Human]
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | TRIB3 |
| Official Name | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] |
| Ensembl ID | ENSG00000101255 |
| Bio databases IDs | |
| Aliases | tribbles pseudokinase 3 |
| Synonyms | C20orf97, HTRB-3, Ifld2, LOC246273, NIPK, SINK, SKIP3, TRB-3, tribbles pseudokinase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein kinase
- protein kinase binding
- protein kinase inhibitor activity
- transcription co-repressor
- serine/threonine kinase domain
- enzyme binding
- enzyme regulator activity
- protein binding
- Protein kinase domain
- enzyme activator activity
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase inhibitor
- Protein Kinases, catalytic domain
Pathways
Biological processes and signaling networks where the TRIB3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- neurodegeneration
- esophageal squamous cell carcinoma
- metastasis
- lung adenocarcinoma
- small cell lung cancer
- organismal death
- colorectal cancer
- lung adenocarcinoma formation
role in cell
- expression in
- proliferation
- apoptosis
- activation in
- degradation in
- binding in
- cell death
- phosphorylation in
- survival
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid biosynthetic process
- regulation of MAP kinase activity
- positive regulation of protein binding
- negative regulation of fat cell differentiation
- negative regulation of protein kinase activity
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to insulin stimulus
- regulation of glucose transport
- positive regulation of ubiquitin-protein ligase activity
- negative regulation of transcription, DNA-dependent
- regulation of autophagy
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- ubiquitin protein ligase binding
- protein binding
- transcription corepressor activity
- ubiquitin-protein ligase regulator activity
- protein kinase inhibitor activity
- kinase activity
- mitogen-activated protein kinase kinase binding