PBX4 Gene Summary [Human]
This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
Details
| Type | Retained Intron |
| Official Symbol | PBX4 |
| Official Name | PBX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:13403] |
| Ensembl ID | ENSG00000105717 |
| Bio databases IDs | |
| Aliases | PBX homeobox 4 |
| Synonyms | 2410015M21Rik, Edg4, Lpa2, PBX homeobox 4, pre B cell leukaemia homeobox 4, pre B cell leukemia homeobox 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PBX4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- PBC domain
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- sex chromatin
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PBX4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- eye development
- positive regulation of transcription, DNA-dependent
- embryonic organ development
- brain development
- neuron development
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- XY body
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity