LYRM7 Gene Summary [Human]
Inner mitochondrial membrane complex III (CIII) is the main enzyme complex in the mitochondrial respiratory chain, and Rieske Fe-S protein (UQCRFS1) is the last catalytic subunit added to the complex. The protein encoded by this gene is a nuclear-encoded mitochondrial matrix protein that stabilizes UQCRFS1 and chaperones it to the CIII complex. Defects in this gene are a cause of mitochondrial complex III deficiency, nuclear type 8. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | LYRM7 |
| Official Name | LYR motif containing 7 [Source:HGNC Symbol;Acc:HGNC:28072] |
| Ensembl ID | ENSG00000186687 |
| Bio databases IDs | |
| Aliases | LYR motif containing 7 |
| Synonyms | 1700024C24Rik, 9330147L21Rik, C5orf31, LOC100041463, LOC100047180, LYR motif containing 7, MC3DN8, MZM1L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LYRM7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complex 1 protein (LYR family)
- protein binding
- LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nuclear type 8 mitochondrial complex III deficiency
- Parkinson disease
- nuclear type 1 mitochondrial complex III deficiency
- mitochondrial disorder
regulated by
- lipopolysaccharide
- TSPO
- beta-estradiol
- THZ531
regulates
- Cytochrome bc1
role in cell
- assembly in
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LYRM7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex III assembly
- cellular respiration
- protein folding
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding involved in protein folding