FPR3 Gene Summary [Human]
Predicted to enable N-formyl peptide receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FPR3 |
| Official Name | formyl peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:3828] |
| Ensembl ID | ENSG00000187474 |
| Bio databases IDs | |
| Aliases | formyl peptide receptor 3 |
| Synonyms | FMLP-R-II, FMLPY, formyl peptide receptor 3, FPRH1, FPRH2, FPRL2, RMLP-R-I |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FPR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cholecystokinin A receptor, N-terminal
- N-formyl peptide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the FPR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- androgenic alopecia
- Tourette syndrome
- asthma
- COVID-19
- dermatomyositis
- renal clear cell adenocarcinoma
- renal clear cell cancer
regulates
- Ca2+
- ERK1/2
- cyclic AMP
- NADPH oxidase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- intracellular space
- cellular membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FPR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- signal transduction
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- complement receptor activity
- protein binding
- N-formyl peptide receptor activity