ANXA1 Gene Summary [Human]
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | ANXA1 |
| Official Name | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] |
| Ensembl ID | ENSG00000135046 |
| Bio databases IDs | |
| Aliases | annexin A1 |
| Synonyms | Annexin-1, annexin A1, ANX1, C430014K04RIK, Lc1, Lipocortin, Lipocortin-1, LPC1, p35 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANXA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- calcium-dependent protein binding
- lipid binding
- nucleic acid binding
- calcium ion binding
- calcium-dependent phospholipid binding
- isomerase
- enzyme
- protein binding
- receptor binding
- identical protein binding
- single-stranded RNA binding
- DNA helicase
- single-stranded DNA binding
- membrane attachment signal
- Annexin
- phospholipase A2 inhibitor
Pathways
Biological processes and signaling networks where the ANXA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe sepsis
- neoplasia
- COVID-19
- precursor B-cell acute lymphoblastic leukemia
- mixed phenotype acute leukemia
- myelodysplastic syndrome
- M2 childhood acute myeloid leukemia
- allergic rhinitis
- T acute lymphoblastic leukemia
- congenital adrenal hyperplasia
role in cell
- phosphorylation in
- apoptosis
- expression in
- signaling in
- activation in
- proliferation
- accumulation
- adhesion
- capture
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- motile cilia
- tip of protrusion
- cornified envelope
- intracellular compartment
- Cytoplasm
- cell-associated matrix
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- actin filaments
- cell-cell contacts
- lipid droplets
- granule matrix
- cytosol
- apical cell surfaces
- membrane ruffles
- apical membrane
- synaptic membrane
- lateral plasma membrane
- mitochondrial membrane
- endosomal membrane
- nucleoplasm
- insulin secretory granules
- sarcolemma
- secretory granules
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANXA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of T-helper 2 cell differentiation
- neutrophil activation
- positive regulation of T-helper 1 cell differentiation
- positive regulation of vesicle fusion
- alpha-beta T cell differentiation
- positive regulation of cell migration involved in sprouting angiogenesis
- negative regulation of exocytosis
- regulation of leukocyte migration
- inflammatory response
- regulation of hormone secretion
- myoblast migration involved in skeletal muscle regeneration
- positive regulation of interleukin-2 production
- positive regulation of wound healing
- positive regulation of G1/S transition of mitotic cell cycle
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- signal transduction
- positive regulation of neutrophil apoptotic process
- adaptive immune response
- cell surface receptor signaling pathway
- positive regulation of T cell proliferation
- neutrophil homeostasis
- keratinocyte differentiation
- arachidonic acid secretion
- monocyte chemotaxis
- innate immune response
- negative regulation of apoptotic process
- cellular response to glucocorticoid stimulus
- negative regulation of interleukin-8 production
- phagocytosis
- regulation of interleukin-1 production
- regulation of inflammatory response
- granulocyte chemotaxis
- cellular response to vascular endothelial growth factor stimulus
- peptide cross-linking
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- extracellular region
- actin filament
- phagocytic cup
- plasma membrane
- nucleoplasm
- cell surface
- early endosome membrane
- nucleus
- motile cilium
- extracellular space
- adherens junction
- cornified envelope
- extracellular vesicular exosome
- endosome
- focal adhesion
- cytoplasm
- sarcolemma
- vesicle membrane
- cytosol
- vesicle
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein binding
- calcium ion binding
- calcium-dependent protein binding
- lipid binding
- phospholipid binding
- receptor binding
- phospholipase A2 inhibitor activity
- calcium-dependent phospholipid binding