IL37 Gene Summary [Human]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL37 |
| Official Name | interleukin 37 [Source:HGNC Symbol;Acc:HGNC:15563] |
| Ensembl ID | ENSG00000125571 |
| Bio databases IDs | |
| Aliases | interleukin 37, interleukin 1, zeta, interleukin-1 homolog 4, interleukin-1-related protein |
| Synonyms | FIL1, FIL1Z, FIL1(ZETA), Fil1 ζ, FIL1(ζ), IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-1 zeta, IL-1 ζ, IL-23, interleukin 37 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-1 receptor binding
- protein binding
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
- identical protein binding
Pathways
Biological processes and signaling networks where the IL37 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- exercise intolerance
- pervasive developmental disorder
- Kawasaki disease
- aortic valve calcification
- shock response
- psoriasis
- ulcerative colitis
- inflammatory bowel disease (infantile ulcerative colitis) 31
- inflammatory bowel disease
- Crohn disease
role in cell
- expression in
- proliferation
- apoptosis
- activation
- production in
- number
- recruitment
- phosphorylation in
- formation in
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Cytoplasm
- Nucleus
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL37 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- immune response
- inflammatory response to antigenic stimulus
- cellular response to lipopolysaccharide
- positive regulation of gene expression
- cytokine-mediated signaling pathway
- regulation of inflammatory response
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- interleukin-1 receptor binding