SELP Gene Summary [Human]
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SELP |
| Official Name | selectin P [Source:HGNC Symbol;Acc:HGNC:10721] |
| Ensembl ID | ENSG00000174175 |
| Bio databases IDs | |
| Aliases | selectin P, antigen CD62, granule membrane protein 140kDa |
| Synonyms | CD62, CD62P, CD62P antigen, GMP-140, GMRP, GRMP, LECAM3, PADGEM, PSEL, PSELECT, P-Selectin, selectin P, selectin, platelet |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SELP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- complement binding domain
- fucose binding
- consensus repeat domain
- cytoplasmic domain
- complement binding protein like domain
- carbohydrate binding
- transmembrane receptor
- SUSHI repeat
- lectin domain
- calcium-dependent protein binding
- extracellular domain
- sphingolipid binding
- lipid binding
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- ectodomain
- calcium ion binding
- signal sequence hydrophobic region
- protein binding
- lipopolysaccharide binding
- EGF-like domain
- CCP
- complement-type repeat
- binding protein
- integrin binding
- transmembrane domain
- Lectin C-type domain
- hinge domain
- cytosolic tail domain
- Sushi repeat (SCR repeat)
- heparin binding
- EGF repeat
Pathways
Biological processes and signaling networks where the SELP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastasis
- neoplasia
- ulcerative colitis
- androgenic alopecia
- lupus nephritis
- edema
- delayed hypersensitive reaction
- Crohn disease
- ulceration
role in cell
- differentiation
- activation in
- migration
- binding
- adhesion
- quantity
- apoptosis
- proliferation
- invasion by
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- membrane surface
- cellular membrane
- vacuole
- vesicles
- lysosome
- secretory granule membrane
- granules
- cytosol
- plasma membrane extracellular face
- alpha granules
- Weibel-Palade bodies
- cytoplasmic vesicles
- multivesicular bodies
- membrane processes
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SELP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- positive regulation of platelet activation
- calcium-dependent cell-cell adhesion
- defense response to Gram-negative bacterium
- heterophilic cell-cell adhesion
- cell adhesion
- leukocyte cell-cell adhesion
- positive regulation of leukocyte migration
- inflammatory response
- response to lipopolysaccharide
- leukocyte tethering or rolling
- regulation of integrin activation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- platelet alpha granule membrane
- external side of plasma membrane
- platelet dense granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- glycosphingolipid binding
- protein binding
- calcium ion binding
- fucose binding
- sialic acid binding
- calcium-dependent protein binding
- integrin binding
- heparin binding
- lipopolysaccharide binding