ZKSCAN3 Gene Summary [Human]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of cellular senescence; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZKSCAN3 |
| Official Name | zinc finger with KRAB and SCAN domains 3 [Source:HGNC Symbol;Acc:HGNC:13853] |
| Ensembl ID | ENSG00000189298 |
| Bio databases IDs | |
| Aliases | zinc finger with KRAB and SCAN domains 3 |
| Synonyms | dJ874C20.1, dJ874C20.1., LOC100507255, ZF47, ZFP306, Zfp307, Zfp-47, zinc finger with KRAB and SCAN domains 3, ZNF306, ZNF309, ZSCAN13, ZSCAN35 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZKSCAN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nuclear export signal
- nucleic acid binding
- SCAN domain
- chromatin binding
- protein binding
- KRAB (Kruppel-associated box) domain -A box
- sequence-specific DNA binding
- DNA binding
- leucine rich region
- krueppel associated box
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- major depression
- plasma cell myeloma
- breast carcinoma
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- lung cancer
role in cell
- proliferation
- migration
- expression in
- activation in
- colony formation
- autophagy by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZKSCAN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- lysosome organization
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- autophagy
- negative regulation of autophagy
- negative regulation of cellular senescence
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity