MPHOSPH8 Gene Summary [Human]
Enables chromatin binding activity and methylated histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; regulation of DNA methylation; and regulation of gene expression. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MPHOSPH8 |
| Official Name | M-phase phosphoprotein 8 [Source:HGNC Symbol;Acc:HGNC:29810] |
| Ensembl ID | ENSG00000196199 |
| Bio databases IDs | |
| Aliases | M-phase phosphoprotein 8 |
| Synonyms | 1500035L22Rik, 4930548G07Rik, AABR07018038.3, Ab2-008, HSMPP8, M-phase phosphoprotein 8, MPHOSPH, mpp8, RGD1305133, TWA3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MPHOSPH8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- histone binding
- transcription regulator
- Ankyrin repeats (many copies)
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- chromatin binding
- protein binding
- Chromo (CHRromatin organization MOdifier) domain
- Ankyrin repeat
- ankyrin repeats
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleosomes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MPHOSPH8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- negative regulation of retroviral genome replication
- hypermethylation of CpG island
- positive regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- cytoplasm
- cytosol
- nucleosome
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding
- chromatin binding