ASMT Gene Summary [Human]

This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

Details

Type
Protein Coding
Official Symbol
ASMT
Official Name
acetylserotonin O-methyltransferase [Source:HGNC Symbol;Acc:HGNC:750]
Ensembl ID
ENSG00000196433
Bio databases IDs NCBI: 438 Ensembl: ENSG00000196433
Aliases acetylserotonin O-methyltransferase
Synonyms acetylserotonin O-methyltransferase, ASMTY, HIOMT, HIOMTY, LOC246281
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASMT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • O-methyltransferase
  • dimerization domain
  • acetylserotonin O-methyltransferase
  • S-methyltransferase
  • protein homodimerization
  • enzyme
  • AdoMet_MTases
  • methyltransferase domain
  • S-adenosylmethionine-dependent methyltransferase
  • identical protein binding

Pathways

Biological processes and signaling networks where the ASMT gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulated by
regulates
  • EP300
  • melatonin
  • indolalkylamine
role in cell
  • translation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ASMT gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • lipid metabolic process
  • melatonin biosynthetic process
  • indolalkylamine biosynthetic process
  • translation
  • methylation

Cellular Component

Where in the cell the gene product is active
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • S-methyltransferase activity
  • O-methyltransferase activity
  • identical protein binding
  • protein homodimerization activity
  • acetylserotonin O-methyltransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.