HSH2D Gene Summary [Human]
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | HSH2D |
| Official Name | hematopoietic SH2 domain containing [Source:HGNC Symbol;Acc:HGNC:24920] |
| Ensembl ID | ENSG00000196684 |
| Bio databases IDs | |
| Aliases | hematopoietic SH2 domain containing |
| Synonyms | ALX, haematopoietic SH2 domain containing, hematopoietic SH2 domain containing, HSH2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSH2D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear export signal
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
role in cell
- apoptosis
- proliferation
- survival
- phagocytosis by
- function
- activation
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- cell surface
- Nucleus
- Mitochondria
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSH2D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding