NSA2 Gene Summary [Human]

This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

Details

Type
Protein Coding
Official Symbol
NSA2
Official Name
NSA2 ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:30728]
Ensembl ID
ENSG00000164346
Bio databases IDs NCBI: 10412 Ensembl: ENSG00000164346
Aliases NSA2 ribosome biogenesis factor, hairy cell leukemia protein 1, TGF beta-inducible nuclear protein 1
Synonyms 5730427N09Rik, CDK105, HCL-G1, HUSSY-29, LNR42, Nsa2p, NSA2 ribosome biogenesis factor, NSA2 ribosome biogenesis homolog, TINP1, YR-29
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NSA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Eukaryotic/archaeal ribosomal protein S8e and similar proteins
  • Ribosomal protein S8e

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic kidney disease
regulated by
regulates
role in cell
  • proliferation
  • cell viability
  • processing in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NSA2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • maturation of 5.8S rRNA
  • maturation of LSU-rRNA

Cellular Component

Where in the cell the gene product is active
  • nucleolus
  • preribosome, large subunit precursor

Molecular Function

What the gene product does at the molecular level
  • RNA binding

Gene-Specific Assays for Results You Can Trust

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