IFNAR1 Gene Summary [Human]
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]
Details
| Type | Protein Coding |
| Official Symbol | IFNAR1 |
| Official Name | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] |
| Ensembl ID | ENSG00000142166 |
| Bio databases IDs | |
| Aliases | interferon alpha and beta receptor subunit 1, IFNalpha/beta receptor 1, type I interferon receptor 1, interferon alpha/beta receptor 1 |
| Synonyms | alpha CHAIN of type I IFNR, AVP, Ifar, IFN-alpha-beta-R, IFNalpha/betaR, Ifn-alpha/beta-receptor, IFN alpha/beta receptor 1, IFN-alpha-REC, IFNAR, IFNBR, IFN receptor CHAIN 1, IFN receptor type 1, IFN type 1 receptor, IFN-α-REC, IFN-α-β-R, Ifn-α/β-receptor, IFN α/β receptor 1, IFRC, IMD106, Infar, interferon (alpha and beta) receptor 1, interferon alpha and beta receptor subunit 1, Interferon Receptor, interferon (α and β) receptor 1, interferon α and β receptor subunit 1, LOC284829, type 1 interferon receptor, Type I IFNR, Type I infr, α CHAIN of type I IFNR, β r1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNAR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytokine binding
- signal peptide
- Interferon-alpha/beta receptor, fibronectin type III
- protein binding
- JAK pathway signal transduction adaptor
- phosphorylation site
- interferon receptor
- interferon-alpha/beta binding
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- interferon-alpha/beta receptor
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IFNAR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Dendritic Cell Maturation
- FAK Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Interferon Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- STAT3 Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- cancer
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- chronic hepatitis B
- hepatitis C
- recurrent melanoma
- plasma cell myeloma
- secondary progressive multiple sclerosis
role in cell
- expression in
- differentiation
- activation in
- proliferation
- apoptosis
- phosphorylation in
- cell viability
- quantity
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNAR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of JAK-STAT cascade
- response to lipopolysaccharide
- response to virus
- cellular response to interferon-alpha
- cellular response to interferon-beta
- type I interferon-mediated signaling pathway
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- late endosome
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- JAK pathway signal transduction adaptor activity
- type I interferon receptor activity
- type I interferon binding
- cytokine binding