Hsh2d Gene Summary [Mouse]
Enables protein-macromolecule adaptor activity. Acts upstream of or within T cell activation; negative regulation of B cell apoptotic process; and negative regulation of mitochondrial depolarization. Located in cytosol and mitochondrion. Is expressed in spleen and thymus. Orthologous to human HSH2D (hematopoietic SH2 domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsh2d |
| Official Name | hematopoietic SH2 domain containing [Source:MGI Symbol;Acc:MGI:2676364] |
| Ensembl ID | ENSMUSG00000062007 |
| Bio databases IDs | |
| Aliases | hematopoietic SH2 domain containing |
| Synonyms | ALX, haematopoietic SH2 domain containing, hematopoietic SH2 domain containing, HSH2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsh2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear export signal
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
role in cell
- apoptosis
- proliferation
- survival
- phagocytosis by
- function
- activation
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- cell surface
- Nucleus
- Mitochondria
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsh2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding