DDI2 Gene Summary [Human]
Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DDI2 |
| Official Name | DNA damage inducible 1 homolog 2 [Source:HGNC Symbol;Acc:HGNC:24578] |
| Ensembl ID | ENSG00000197312 |
| Bio databases IDs | |
| Aliases | DNA damage inducible 1 homolog 2 |
| Synonyms | 1110056G13Rik, 1700027M01Rik, 9130022E05Rik, DNA damage inducible 1 homolog 2, DNA-damage inducible protein 2, RGD1311815 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- Ubl1_cv_Nsp3_N-like
- peptidase
- aspartic endopeptidase
- ubiquitin binding
- protein binding
- Cellular and retroviral pepsin-like aspartate proteases
- identical protein binding
- gag-polyprotein putative aspartyl protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholic pancreatitis
role in cell
- expression in
- activation in
- transactivation in
- cadmium sensitivity
- response by
- endoplasmic reticulum-associated degradation in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- cellular response to hydroxyurea
- protein processing
- proteasomal protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- aspartic-type endopeptidase activity
- ubiquitin binding