MT1G Gene Summary [Human]
Enables zinc ion binding activity. Involved in cellular response to metal ion; cellular response to vascular endothelial growth factor stimulus; and negative regulation of growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MT1G |
| Official Name | metallothionein 1G [Source:HGNC Symbol;Acc:HGNC:7399] |
| Ensembl ID | ENSG00000125144 |
| Bio databases IDs | |
| Aliases | metallothionein 1G, metallothionein 1K |
| Synonyms | metallothionein 1G, MT1, MT1K |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MT1G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- Metallothionein
- protein binding
Pathways
Biological processes and signaling networks where the MT1G gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- hepatocellular carcinoma
- liver cancer
- endometriosis
- rheumatoid arthritis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Huntington disease
- abdominal aortic aneurysm
role in cell
- apoptosis
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MT1G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- detoxification of copper ion
- cellular response to zinc ion
- cellular response to cadmium ion
- cellular zinc ion homeostasis
- cellular response to vascular endothelial growth factor stimulus
- cellular response to copper ion
- monocyte differentiation
- monocyte activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metal ion binding