KLHL14 Gene Summary [Human]
The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | KLHL14 |
| Official Name | kelch like family member 14 [Source:HGNC Symbol;Acc:HGNC:29266] |
| Ensembl ID | ENSG00000197705 |
| Bio databases IDs | |
| Aliases | kelch like family member 14, printor |
| Synonyms | 6330403N15Rik, kelch-like 14, kelch-like family member 14, printor, RGD1566178 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHL14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- actin cytoskeleton
- Endoplasmic Reticulum
- cytosol
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHL14 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- actin cytoskeleton
- cytosol
- endoplasmic reticulum
- neuronal cell body
- aggresome
- neuron projection