TSEN15 Gene Summary [Human]
This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | TSEN15 |
| Official Name | tRNA splicing endonuclease subunit 15 [Source:HGNC Symbol;Acc:HGNC:16791] |
| Ensembl ID | ENSG00000198860 |
| Bio databases IDs | |
| Aliases | tRNA splicing endonuclease subunit 15 |
| Synonyms | 5730449L18RIK, C1orf19, D6Mgi32, PCH2F, RGD1308584, SEN15, tRNA splicing endonuclease subunit 15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSEN15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA-intron endonuclease
- Sen15 protein
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSEN15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA splicing, via endonucleolytic cleavage and ligation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding