MIER1 Gene Summary [Human]

This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

Details

Type
Protein Coding
Official Symbol
MIER1
Official Name
MIER1 transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:29657]
Ensembl ID
ENSG00000198160
Bio databases IDs NCBI: 57708 Ensembl: ENSG00000198160
Aliases MIER1 transcriptional regulator
Synonyms 4933425I22Rik, 5830411K19RIK, ER1, MEIR1 treanscription regulator, MIER1 transcriptional regulator, RGD1562337
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIER1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SANT
  • transcription regulator
  • SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
  • ELM2 domain
  • Myb-like DNA-binding domain
  • histone deacetylase
  • histone deacetylase binding
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • inflammatory bowel disease
  • allergic rhinitis
regulated by
regulates
role in cell
  • growth
  • remodeling

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MIER1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin remodeling
  • positive regulation of I-kappaB kinase/NF-kappaB cascade
  • regulation of transcription, DNA-dependent

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • transcriptional repressor complex
  • macromolecular complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • histone deacetylase activity
  • histone deacetylase binding
  • transcription corepressor activity

Gene-Specific Assays for Results You Can Trust

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