DENND4B Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity. Involved in regulation of Rab protein signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | DENND4B |
| Official Name | DENN domain containing 4B [Source:HGNC Symbol;Acc:HGNC:29044] |
| Ensembl ID | ENSG00000198837 |
| Bio databases IDs | |
| Aliases | DENN domain containing 4B |
| Synonyms | DENN domain containing 4B, KIAA0476, RGD1560320 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DENND4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PPR repeat
- pentatricopeptide repeat domain (PPR motif)
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- Stabilization of polarity axis
- PPR repeat family
- dDENN domain
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DENND4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rab protein signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- cytoplasmic vesicle
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity