GSTT1 Gene Summary [Human]
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | GSTT1 |
| Official Name | glutathione S-transferase theta 1 [Source:HGNC Symbol;Acc:HGNC:4641] |
| Ensembl ID | ENSG00000277656 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase theta 1 |
| Synonyms | clone 322B1, EC 2.5.1.18, glutathione S-transferase theta 1, glutathione S-transferase, theta 1, Glutathione S-transferase, theta 1, non-human, glutathione S-transferase θ 1, glutathione S-transferase, θ 1, Glutathione S-transferase, θ 1, non-human, GSTT1-1, Gst y1, GSTYRS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSTT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- alkylhalidase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- glutathione peroxidase
- protein binding
Pathways
Biological processes and signaling networks where the GSTT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- bladder cancer
- cancer
- epithelial cancer
- lung cancer
- skin cancer
- colorectal cancer
- metastatic colorectal cancer
- prostate cancer
- renal cancer
regulates
- glutathione
- ethylene oxide
- methylene chloride
- xenobiotic
- ethylene dibromide
- 1,2-epoxy-3-(p-nitrophenoxy)propane
- cumene hydroperoxide
- 1-bromo-4-nitrobenzene
- epoxide
- 1-chloro-2,4-dinitrobenzene
role in cell
- frequency
- apoptosis
- cytotoxic reaction
- sister chromatid exchange in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- vesicles
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSTT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- glutathione peroxidase activity
- protein binding
- glutathione transferase activity