NYNRIN Gene Summary [Human]
Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NYNRIN |
| Official Name | NYN domain and retroviral integrase containing [Source:HGNC Symbol;Acc:HGNC:20165] |
| Ensembl ID | ENSG00000205978 |
| Bio databases IDs | |
| Aliases | NYN domain and retroviral integrase containing, Cousin of GIN1 |
| Synonyms | AA409373, C80530, CGIN1, KIAA1305, mKIAA1305, NYN domain and retroviral integrase containing |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NYNRIN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNAse H
- Integrase zinc binding domain
- K homology (KH) RNA-binding domain, type I
- RNase H-like domain found in reverse transcriptase
- Zc3h12a-like Ribonuclease NYN domain
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- cancer
- neuroblastoma
- neuroblastoma formation
- Wilms tumorigenesis
- mixed neoplasia
- renal cancer
- renal neoplasia
- retroperitoneal cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NYNRIN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- DNA integration
- DNA synthesis involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
Molecular Function
What the gene product does at the molecular level
- ribonuclease H activity
- mRNA binding
- endoribonuclease activity