Nynrin Gene Summary [Mouse]
Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in DNA integration. Predicted to be located in membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human NYNRIN (NYN domain and retroviral integrase containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nynrin |
| Official Name | NYN domain and retroviral integrase containing [Source:MGI Symbol;Acc:MGI:2652872] |
| Ensembl ID | ENSMUSG00000075592 |
| Bio databases IDs | |
| Aliases | NYN domain and retroviral integrase containing |
| Synonyms | AA409373, C80530, CGIN1, KIAA1305, mKIAA1305, NYN domain and retroviral integrase containing |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nynrin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNAse H
- Integrase zinc binding domain
- K homology (KH) RNA-binding domain, type I
- RNase H-like domain found in reverse transcriptase
- Zc3h12a-like Ribonuclease NYN domain
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- cancer
- neuroblastoma
- neuroblastoma formation
- Wilms tumorigenesis
- mixed neoplasia
- renal cancer
- renal neoplasia
- retroperitoneal cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nynrin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication
- DNA integration
- DNA synthesis involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
Molecular Function
What the gene product does at the molecular level
- ribonuclease H activity
- mRNA binding
- endoribonuclease activity