IGLC1
IGLC1 Gene Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGLC1 |
| Official Name | immunoglobulin lambda constant 1 [Source:HGNC Symbol;Acc:HGNC:5855] |
| Ensembl ID | ENSG00000211675 |
| Bio databases IDs | |
| Aliases | immunoglobulin lambda constant 1 |
| Synonyms | IGLC,immunoglobulin lambda constant 1,immunoglobulin λ constant 1 |
| Species | Human, Homo sapiens |
Pathways
Biological processes and signaling networks where the IGLC1 gene plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-15 Signaling
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TRIM67
- WWOX
- NTPCR
- IGHG1
- NSD2
- FOXO1
- UBQLN1
- SERPINA1
- IGHV3-33
- SGTA
disease
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
regulated by
- IFNG
- methylprednisolone
- imatinib
- pexidartinib
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Plasma Membrane
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IGLC1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- immune response
- immunoglobulin mediated immune response
- adaptive immune response
- B cell receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- IgD immunoglobulin complex
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- IgM immunoglobulin complex
- IgE immunoglobulin complex
- extracellular region
- plasma membrane
- IgA immunoglobulin complex
- IgG immunoglobulin complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- antigen binding