TRGC1 Gene Summary [Human]
In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein. [provided by RefSeq, Jul 2008]
Details
| Type | T-Cell Receptor Constant Gene |
| Official Symbol | TRGC1 |
| Official Name | T cell receptor gamma constant 1 [Source:HGNC Symbol;Acc:HGNC:12275] |
| Ensembl ID | ENSG00000211689 |
| Bio databases IDs | |
| Aliases | T cell receptor gamma constant 1, T-cell receptor, gamma, constant region C1 |
| Synonyms | CD3G, TCR gamma alternate reading frame protein, TCR γ alternate reading frame protein |
| Species | Human, Homo sapiens |
Pathways
Biological processes and signaling networks where the TRGC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antiproliferative Role of TOB in T Cell Signaling
- Autoimmune Thyroid Disease Signaling
- Calcium-induced T Lymphocyte Apoptosis
- CCR5 Signaling in Macrophages
- Cdc42 Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Dendritic Cell Maturation
- G Protein Signaling Mediated by Tubby
- Graft-versus-Host Disease Signaling
- IL-4 Signaling
- Lipid Antigen Presentation by CD1
- NF-κB Signaling
- Nur77 Signaling in T Lymphocytes
- OX40 Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- SAPK/JNK Signaling
- T Cell Receptor Signaling
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- juvenile rheumatoid arthritis
- asthma
- polymyositis
- chronic obstructive pulmonary disease
- Crohn disease
- ulcerative colitis
- Alzheimer disease
- epithelial cancer
- chronic fatigue syndrome
- malignant pleural mesothelioma
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- microsome
- mitochondrial outer membrane