INPP4B Gene Summary [Human]
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | INPP4B |
| Official Name | inositol polyphosphate-4-phosphatase type II B [Source:HGNC Symbol;Acc:HGNC:6075] |
| Ensembl ID | ENSG00000109452 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-4-phosphatase type II B |
| Synonyms | E130107I17RIK, inositol polyphosphate-4-phosphatase, type II, inositol polyphosphate-4-phosphatase type II B, IPP4P2A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INPP4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inositol-1,3,4-trisphosphate 4-phosphatase
- lipid binding
- inositol bisphosphate phosphatase
- phosphatase
- protein binding
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- hypertension
- osteoporosis
- neoplasia
- acute myeloid leukemia
- tumorigenesis
- metastasis
- malaria
- organismal death
- alcoholism
role in cell
- expression in
- proliferation
- quantity
- phosphorylation in
- activation in
- growth
- migration
- number
- formation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INPP4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- signal transduction
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol biosynthetic process
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
- protein binding
- inositol-1,3,4-trisphosphate 4-phosphatase activity
- inositol-3,4-bisphosphate 4-phosphatase activity