SCAF8 Gene Summary [Human]
Enables RNA binding activity and RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled and positive regulation of DNA-templated transcription, elongation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SCAF8 |
| Official Name | SR-related CTD associated factor 8 [Source:HGNC Symbol;Acc:HGNC:20959] |
| Ensembl ID | ENSG00000213079 |
| Bio databases IDs | |
| Aliases | SR-related CTD associated factor 8 |
| Synonyms | A630086M08RIK, A930036P18Rik, AA408306, LOC245926, mKIAA1116, RBM16, SR-related CTD-associated factor 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCAF8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA Pol II CTD binding domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- VHS, ENTH and ANTH domain superfamily
- enzyme binding
- CID domain
- protein domain specific binding
- protein binding
- phosphoprotein amino acid binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear matrix fraction
- nucleolar region
- nucleoplasm
- nuclear matrix
- extranucleolar nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCAF8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
- termination of RNA polymerase II transcription
- positive regulation of transcription elongation, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mRNA cleavage factor complex
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- RNA polymerase core enzyme binding
- mRNA binding
- RNA polymerase II core binding