THRSP Gene Summary [Human]
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | THRSP |
| Official Name | thyroid hormone responsive [Source:HGNC Symbol;Acc:HGNC:11800] |
| Ensembl ID | ENSG00000151365 |
| Bio databases IDs | |
| Aliases | thyroid hormone responsive, SPOT14 homolog (rat) |
| Synonyms | c-ErbA α, Hepatic Product Spot 14, Lpgp, LPGP1, S14, SPOT14, T3r α, THRP, thyroid hormone receptor α, thyroid hormone receptor α 1, thyroid hormone responsive, Tr α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THRSP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nhr2 domain
- Thyroid hormone-inducible hepatic protein Spot 14
- protein homodimerization
- protein binding
- identical protein binding
- acidic domain
Pathways
Biological processes and signaling networks where the THRSP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- psoriasis
- hepatocellular carcinoma
- liver cancer
- senile lentigo
- thyroid carcinoma
- epithelial thyroid cancer
role in cell
- expression in
- cell viability
- morphology
- metabolism by
- transactivation in
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THRSP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lipid biosynthetic process
- response to bacterium
- lipid metabolic process
- regulation of triglyceride biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding