KIFC3 Gene Summary [Human]
This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | KIFC3 |
| Official Name | kinesin family member C3 [Source:HGNC Symbol;Acc:HGNC:6326] |
| Ensembl ID | ENSG00000140859 |
| Bio databases IDs | |
| Aliases | kinesin family member C3 |
| Synonyms | BB123200, kinesin family member C3, KRP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIFC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial type III secretion protein (HrpB7)
- Ciliary protein causing Leber congenital amaurosis disease
- Myosin and Kinesin motor domain
- enzyme
- protein binding
- Bin/Amphiphysin/Rvs domain
- motor domain
- identical protein binding
- microtubule motor protein
- Kinesin motor, catalytic domain
- Domain of unknown function (DUF4201)
- microtubule binding
- Trichohyalin-plectin-homology domain
- Kinesin motor domain
- minus-end-directed kinesin ATPase
- Apolipoprotein A1/A4/E domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- proliferation
- migration
- survival
- fragmentation
- stabilization in
- scattering
- stabilization
- organization
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- perinuclear region
- vesicles
- centrosome
- Golgi Apparatus
- Mitochondria
- endocytotic vesicle
- zonula adherens
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIFC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell-cell adhesion
- Golgi organization
- visual perception
- zonula adherens maintenance
- microtubule-based movement
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centrosome
- cytoplasmic vesicle membrane
- extracellular vesicular exosome
- zonula adherens
- kinesin complex
- Golgi apparatus
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- microtubule motor activity
- protein binding
- microtubule binding