COL28A1 Gene Summary [Human]
COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | COL28A1 |
| Official Name | collagen type XXVIII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:22442] |
| Ensembl ID | ENSG00000215018 |
| Bio databases IDs | |
| Aliases | collagen type XXVIII alpha 1 chain |
| Synonyms | COL28, collagen, type XXVIII, alpha 1, collagen type XXVIII alpha 1 chain, collagen, type XXVIII, α 1, collagen type XXVIII α 1 chain, Collagen xxviii, Col xxviii, Gm466, RGD1564680 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COL28A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- von Willebrand factor (vWF) type A domain
- vWFA
- Collagen triple helix repeat (20 copies)
- von Willebrand factor type A domain
Pathways
Biological processes and signaling networks where the COL28A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COL28A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- basement membrane
- extracellular region
- collagen type V
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- extracellular matrix structural constituent conferring tensile strength
- heparin binding