UBXN2B Gene Summary [Human]
Predicted to enable ubiquitin binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and spindle pole centrosome. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBXN2B |
| Official Name | UBX domain protein 2B [Source:HGNC Symbol;Acc:HGNC:27035] |
| Ensembl ID | ENSG00000215114 |
| Bio databases IDs | |
| Aliases | UBX domain protein 2B |
| Synonyms | 3110003A22Rik, 6430407D20Rik, p37, RGD1308557, UBX domain protein 2B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBXN2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SEP domain
- Ubl1_cv_Nsp3_N-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBXN2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- establishment of mitotic spindle orientation
- proteasomal ubiquitin-dependent protein catabolic process
- membrane fusion
- Golgi organization
- positive regulation of mitotic centrosome separation
- nuclear envelope reassembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle pole centrosome
- cytosol
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding