INCA1 Gene Summary [Human]
Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | INCA1 |
| Official Name | inhibitor of CDK, cyclin A1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:32224] |
| Ensembl ID | ENSG00000196388 |
| Bio databases IDs | |
| Aliases | inhibitor of CDK, cyclin A1 interacting protein 1 |
| Synonyms | HSD45, inhibitor of CDK, cyclin A1 interacting protein 1, LOC100359866, RGD1306656 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INCA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase inhibitor activity
- INCA1
- binding protein
- protein binding
- identical protein binding
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- childhood pro-B-cell acute lymphoblastic leukemia
- acute myeloid leukemia
- childhood acute lymphoblastic leukemia
- T acute lymphoblastic leukemia
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INCA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- negative regulation of fibroblast proliferation
- negative regulation of cell proliferation
- apoptotic signaling pathway
- negative regulation of cyclin-dependent protein kinase activity
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cyclin binding
- cyclin-dependent protein kinase inhibitor activity