PPP1CC Gene Summary [Human]
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | PPP1CC |
| Official Name | protein phosphatase 1 catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:9283] |
| Ensembl ID | ENSG00000186298 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 catalytic subunit gamma |
| Synonyms | dis2m1, LOC360258, LOC627816, PP1, PP1C, PP1C gamma, PP1c gamma1, PP1C γ, PP-1G, Pp1g1, PP1 gamma, PP1 γ, Pp1 γ c, Ppp1cc1, PPP1G, protein phosphatase 1 catalytic subunit gamma, protein phosphatase 1 catalytic subunit γ, Protein Phosphatase 1 gamma, Protein Phosphatase 1 γ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1CC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine-threonine protein phosphatase N-terminal domain
- protein kinase binding
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- protein phosphatase binding
- lamin binding
- protein domain specific binding
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- core domain, functional
- Calcineurin-like phosphoesterase
- protein phosphatase 1 binding
- binding protein
- protein phosphatase
- phosphatase
- Protein phosphatase 2A homologues, catalytic domain
Pathways
Biological processes and signaling networks where the PPP1CC gene in human plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- Breast Cancer Regulation by Stathmin1
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- EIF2 Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- Insulin Receptor Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Protein Kinase A Signaling
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic lymphocytic leukemia
- mammary neoplasm
- oligozoospermia
- globozoospermia
- chronic epilepsy
role in cell
- expression in
- cell death
- survival
- activation in
- growth
- apoptosis
- proliferation
- phosphorylation in
- cell viability
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- postsynaptic density (PSD) fractions
- polyribosome fractions
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- postsynaptic region
- Plasma Membrane
- spindle pole bodies
- centrosome
- Mitochondria
- midbody
- cytosol
- mitochondrial outer membrane
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- dendritic spines
- neurites
- synaptosomes
- microsomal membrane
- membrane rafts
- cleavage furrow
- kinetochores
- telomeres
- chromatin
- perikaryon
- dendrites
- postsynaptic density
- basement membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1CC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- spermatogenesis
- protein dephosphorylation
- positive regulation of glial cell proliferation
- regulation of circadian rhythm
- regulation of nucleocytoplasmic transport
- cell division
- MAPK cascade
- circadian regulation of gene expression
- glycogen metabolic process
- entrainment of circadian clock by photoperiod
- blastocyst development
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- nuclear speck
- kinetochore
- nucleolus
- mitochondrial outer membrane
- chromosome, telomeric region
- nucleus
- focal adhesion
- microtubule organizing center
- cytoplasm
- mitochondrion
- dendritic spine
- cytosol
- macromolecular complex
- PTW/PP1 phosphatase complex
- midbody
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- phosphoprotein phosphatase activity
- protein kinase binding
- protein domain specific binding
- protein binding
- RNA binding
- metal ion binding
- phosphatase activity
- protein phosphatase 1 binding
- lamin binding
- myosin phosphatase activity