GRXCR1 Gene Summary [Human]
This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | GRXCR1 |
| Official Name | glutaredoxin and cysteine rich domain containing 1 [Source:HGNC Symbol;Acc:HGNC:31673] |
| Ensembl ID | ENSG00000215203 |
| Bio databases IDs | |
| Aliases | glutaredoxin and cysteine rich domain containing 1, protein phosphatase 1, regulatory subunit 88 |
| Synonyms | DFNB25, glutaredoxin and cysteine rich domain containing 1, glutaredoxin, cysteine rich 1, LOC100910415, pi, PPP1R88, RGD1564635, tde, Tg(Eno2-Gabrb3)0370Brll |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRXCR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- kinocilia
- cytosol
- stereocilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRXCR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- inner ear receptor stereocilium organization
- auditory receptor cell differentiation
- cochlea development
- vestibular receptor cell development
- inner ear receptor cell development
Cellular Component
Where in the cell the gene product is active
- microvillus
- kinocilium
- stereocilium
Molecular Function
What the gene product does at the molecular level
- protein binding