Grxcr1 Gene Summary [Mouse]
Involved in inner ear receptor cell stereocilium organization; sensory perception of sound; and vestibular receptor cell development. Acts upstream of or within several processes, including inner ear development; response to acetylcholine; and response to calcium ion. Located in kinocilium and stereocilium. Is expressed in endolymphatic duct; inner ear vestibular component; and utricle. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Orthologous to human GRXCR1 (glutaredoxin and cysteine rich domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grxcr1 |
| Official Name | glutaredoxin, cysteine rich 1 [Source:MGI Symbol;Acc:MGI:3577767] |
| Ensembl ID | ENSMUSG00000068082 |
| Bio databases IDs | |
| Aliases | glutaredoxin, cysteine rich 1 |
| Synonyms | DFNB25, glutaredoxin and cysteine rich domain containing 1, glutaredoxin, cysteine rich 1, LOC100910415, pi, PPP1R88, RGD1564635, tde, Tg(Eno2-Gabrb3)0370Brll |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grxcr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- kinocilia
- cytosol
- stereocilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grxcr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- inner ear receptor stereocilium organization
- auditory receptor cell differentiation
- cochlea development
- vestibular receptor cell development
- inner ear receptor cell development
Cellular Component
Where in the cell the gene product is active
- microvillus
- kinocilium
- stereocilium
Molecular Function
What the gene product does at the molecular level
- protein binding