MIAT Gene Summary [Human]
This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | MIAT |
| Official Name | myocardial infarction associated transcript [Source:HGNC Symbol;Acc:HGNC:33425] |
| Ensembl ID | ENSG00000225783 |
| Bio databases IDs | |
| Aliases | myocardial infarction associated transcript, non-protein coding RNA 66, long intergenic non-protein coding RNA 66 |
| Synonyms | 3632434I06, A230057G18Rik, C22orf35, GOMAFU, LINC00066, lncRNA-MIAT, myocardial infarction associated transcript, myocardial infarction associated transcript (non-protein coding), NCRNA00066, RNCR2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIAT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- STAT3
- NFkB (complex)
- miR-378a-5p (miRNAs w/seed UCCUGAC)
disease
- heart disease
- heart failure
- HER2 negative hormone receptor negative breast cancer
- streptozotocin-induced diabetes
- cardiac fibrosis
- interstitial fibrosis
- breast cancer
- small cell lung cancer
- cardiac remodeling
- diabetes mellitus
role in cell
- apoptosis
- proliferation
- migration
- expression in
- growth
- production in
- quantity
- differentiation
- survival
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear bodies