Miat Gene Summary [Mouse]

This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. This transcript has been associated with retinal cell fate determination. Altered expression of a similar gene in human has been associated with a susceptibility to myocardial infarction, and is involved in pathways that may contribute to the pathophysiology of schizophrenia. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]

Details

Type
Long Non-Coding RNA
Official Symbol
Miat
Official Name
myocardial infarction associated transcript (non-protein coding) [Source:MGI Symbol;Acc:MGI:2444886]
Ensembl ID
ENSMUSG00000097767
Bio databases IDs NCBI: 330166 Ensembl: ENSMUSG00000097767
Aliases myocardial infarction associated transcript (non-protein coding)
Synonyms 3632434I06, A230057G18Rik, C22orf35, GOMAFU, LINC00066, lncRNA-MIAT, myocardial infarction associated transcript, myocardial infarction associated transcript (non-protein coding), NCRNA00066, RNCR2
Species
Mouse, Mus musculus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Miat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • STAT3
  • NFkB (complex)
  • miR-378a-5p (miRNAs w/seed UCCUGAC)
disease
  • heart disease
  • heart failure
  • HER2 negative hormone receptor negative breast cancer
  • streptozotocin-induced diabetes
  • cardiac fibrosis
  • interstitial fibrosis
  • breast cancer
  • small cell lung cancer
  • cardiac remodeling
  • diabetes mellitus
regulated by
  • beta-estradiol
  • AGT
  • D-glucose
  • POU5F1
  • cobalt chloride
  • mir-150 (includes others)
  • hydrogen peroxide
  • Bay 11-7082
  • fibroblasts
  • TARDBP
role in cell
  • apoptosis
  • proliferation
  • migration
  • expression in
  • growth
  • production in
  • quantity
  • differentiation
  • survival
  • cell viability

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear bodies

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.