S100A10 Gene Summary [Human]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | S100A10 |
| Official Name | S100 calcium binding protein A10 [Source:HGNC Symbol;Acc:HGNC:10487] |
| Ensembl ID | ENSG00000197747 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A10, annexin II tetramer (AIIt) p11 subunit, calpactin I |
| Synonyms | 42C, Annexin2 Light Chain, ANX2L, ANX2LG, Ca[1], CAL12, CAL1L, Calpactin, CLP11, GP11, p10, P11, S100 calcium binding protein A10, S100 calcium binding protein A10 (calpactin), S-100-related |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S100A10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- lysine rich domain
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- protein homodimerization
- ion channel binding
- EFh
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- rheumatoid arthritis
- osteoarthritis
- lung cancer
- lung carcinoma process
- epithelial cancer
- thoracic cancer
- epithelial neoplasia
- Parkinson disease
- gastric adenocarcinoma
role in cell
- activation
- density
- expression in
- colony formation
- invasion by
- migration
- growth
- apoptosis
- binding in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- basal compartment
- Plasma Membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S100A10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of GTPase activity
- positive regulation of exocytosis
- positive regulation of focal adhesion assembly
- membrane budding
- membrane raft assembly
- positive regulation of stress fiber assembly
- positive regulation of plasminogen activation
- regulation of neurogenesis
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane raft
- nuclear matrix
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- calcium ion binding
- calcium-dependent protein binding
- lipid binding
- ion channel binding