SLFN12 Gene Summary [Human]
Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLFN12 |
| Official Name | schlafen family member 12 [Source:HGNC Symbol;Acc:HGNC:25500] |
| Ensembl ID | ENSG00000172123 |
| Bio databases IDs | |
| Aliases | schlafen family member 12 |
| Synonyms | schlafen family member 12, SLFN3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLFN12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative DNA-binding domain
- ribonuclease
- ribosome binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tinnitus
role in cell
- cell viability
- expression in
- replication in
- DNMDP sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLFN12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA catabolic process
- apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding
- ribonuclease activity