MIF Gene Summary [Human]
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MIF |
| Official Name | macrophage migration inhibitory factor [Source:HGNC Symbol;Acc:HGNC:7097] |
| Ensembl ID | ENSG00000240972 |
| Bio databases IDs | |
| Aliases | macrophage migration inhibitory factor, glycosylation-inhibiting factor, phenylpyruvate tautomerase |
| Synonyms | DER6, GIF, GLIF, LOC103694877, MACROPHAGE INHIBITOR FACTOR, Macrophage migration inhibitory factor, macrophage migration inhibitory factor (glycosylation-inhibiting factor), Mif1, MMIF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dopachrome isomerase
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- binding protein
- protease binding
- chemoattractant
- phenylpyruvate tautomerase
- 4Oxalocrotonate_Tautomerase
- protein binding
- cytokine
- identical protein binding
- Macrophage migration inhibitory factor (MIF)
Pathways
Biological processes and signaling networks where the MIF gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- heart disease
- breast carcinoma
- colorectal cancer
- neoplasia
- bleeding
- obesity
- inflammatory disorder
- impaired glucose tolerance
- splenomegaly
role in cell
- activation in
- growth
- production in
- expression in
- activation
- loss
- binding
- migration
- invasion by
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myelin enriched fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- cell surface
- Plasma Membrane
- centriole
- cytosol
- nucleoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of arachidonic acid secretion
- positive regulation of prostaglandin secretion involved in immune response
- positive chemotaxis
- positive regulation of cell proliferation
- cellular senescence
- positive regulation of protein kinase A signaling cascade
- inflammatory response
- regulation of macrophage activation
- positive regulation of fibroblast proliferation
- positive regulation of myeloid leukocyte cytokine production involved in immune response
- positive regulation of tumor necrosis factor production
- protein homotrimerization
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of protein metabolic process
- negative regulation of cellular senescence
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of phosphorylation
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of myeloid cell apoptotic process
- cell surface receptor signaling pathway
- negative regulation of gene expression
- innate immune response
- negative regulation of apoptotic process
- prostaglandin biosynthetic process
- positive regulation of ERK1 and ERK2 cascade
- DNA damage response, signal transduction by p53 class mediator
- positive regulation of chemokine (C-X-C motif) ligand 2 production
- positive regulation of B cell proliferation
- carboxylic acid metabolic process
- negative regulation of mature B cell apoptotic process
- positive regulation of lipopolysaccharide-mediated signaling pathway
- negative regulation of macrophage chemotaxis
- positive regulation of cytokine production
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- vesicle
- cytosol
- secretory granule lumen
- extracellular region
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phenylpyruvate tautomerase activity
- identical protein binding
- protein binding
- chemoattractant activity
- protease binding
- cytokine activity
- dopachrome isomerase activity
- cytokine receptor binding